Antibiotics – associated myopathies : The current update
نویسندگان
چکیده
The muscle tissue appears particularly susceptible to drug – related injuries. Drug – related myopathies can vary in their clinical presentations, starting from mild myalgias, going through myositis, all the way to severe rhabdomyolysis. At the cellular level, drug – associated myopathies most generally result in necrosis, vacuolar changes, or mitochondrial dysfunction. The most common factors that increase the risk of drug – induced myotoxicity include: advanced age, administration of multiple myotoxic drugs, high doses of myotoxic drugs, female gender, thyroid disease, existing hepatic or renal disease, perioperative period of surgery, existence of metabolic muscle disease or genetic polymorphisms. Accordingly, highly individualized and well-timed assessment of the risks and benefits of prescribing potentially myotoxic drugs must be a paramount. Taking into account previous facts, as well as the increasing frequency of reports related to antibiotics – associated myopathies, the aim of this article was to review the current knowledge related to muscular complications associated with use of different antibiotics by adults, including fluoroquinolones, hydroxychloroquine, chloroquine, minocycline, trimethoprimsulphamethoxazole, isoniazid and daptomycin. Correspondence/Reprint request: Dr. Miroslav Radenković, Department of Pharmacology, Clinical Pharmacology and Toxicology, Medical Faculty, University of Belgrade, P.O. Box 38, 11129 Belgrade, Serbia E-mail: [email protected] Miroslav Radenković 144
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تاریخ انتشار 2015